Phencyclidine (PCP)

CPT Code: 

80101 

Specimen: 

Urine 

Volume: 

30 mL 

Container: 

Use plastic urine drug bottle and evidence tape or tamper-evident container for forensic specimen. Collection kits are available by request from the laboratory. 

Collection:

Urine specimens should be collected in clean, unbreakable, and leak proof containers.  Freshly voided urine specimens should be used.

Fresh urine specimens do not require any special pretreatment.  No additives or preservatives are required.  Boric acid should not be used as a preservative.

Specimens may be encountered that display turbidity.  It is recommended that such specimens be centrifuged before analysis.

Specimens should be within the pH range of 5-8.  Specimens with a pH outside this range should be adjusted to this range by the addition of 1N HCl or 1N NaOH before analysis.

Specimens should be at a temperature of 20-25 ⁰C before analysis.

Stability: 

If not analyzed immediately, specimens should be stored refrigerated for less than 24 hours.  Specimens should be frozen if storage longer than 24 hours is required.

Cutoff:

25 ng/mL

Note: This method provides only a preliminary analytical test result.  A more specific alternate chemical method must be used in order to obtain a confirmed analytical result.  Gas chromatography/mass spectrometry (GC/MS) is the preferred confirmatory method.  Other chemical confirmation methods are available.  Clinical consideration and professional judgment should be applied to any drug of abuse test result, particularly when preliminary positive results are used.

Use: 

Measurements obtained with PCP method are used in the diagnosis and treatment of phencyclidine use or overdose.

Information: 

Phencyclidine, also known as PCP and “angel dust”, is a synthetic drug that was originally developed for its anesthetic properties but is now a drug of abuse used solely for its potent hallucinogenic effects.  It may be self-administered in a variety of ways, including ingestion, inhalation, and intravenous injection.  Phencyclidine is absorbed well and quickly, and concentrates in the brain and fatty tissues.  Excretion patterns vary widely, ranging from several hours to a couple of weeks.  Phencyclidine is excreted in the urine unchanged, as conjugated metabolites, and primarily as unidentified compounds.

Methodology: 

EMIT®